Research Paper Volume 12, Issue 4 pp 3862—3879

Acetate attenuates perioperative neurocognitive disorders in aged mice

Figure 4. Surgery-induced ROS overproduction and IBA-1 activation in the hippocampus were suppressed by acetate administration (n=5). (A) Green fluorescence indicates 8-OH-dG levels on POD 1 and POD 7. (B) Bar graphs display the quantification of 8-OH-dG in the hippocampus. (C) Representative images of IBA-1 expression on POD 1 and POD 7. (D) Bar graphs indicate the cell body/cell size of IBA-1-labeled microglia in the four groups. Data are expressed as the mean±SEM, *P<0.05 vs. the normal and acetate groups, #P<0.05 vs. the surgery group. ACE: acetate. Scale bar = 50 μm.