Research Paper Volume 12, Issue 5 pp 4178—4192

SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity

Figure 1. SIRT3 overexpression inhibits the expression of mRNA levels of ANF and BNP. In H9c2 cells, Ad-GFP or Ad-SIRT3 were transfected and then stimulated with 10 uM ISO or 100 uM PE for 24 h. RNA was extracted and mRNA expression of ANF and BNP was detected by qRT-PCR. Data were presented as means±SE. *P<0.05 versus control or GFP group, #P<0.05 versus GFP treated with ISO or PE, n=4 independent experiments.