Research Paper Volume 12, Issue 4 pp 3950—3961

Advanced maternal age alters expression of maternal effect genes that are essential for human oocyte quality

Figure 1. Fertility declines in women with advanced reproductive age. (A) The morphology of matured oocyte from a younger and an older female patient. Bars = 50μm. (B) Younger (27.6 ± 1.3 years, n = 170) and older women (41.6 ± 1.8 years, n = 183) MII oocyte area, without zona pellucida. Unpaired two-tailed t-test. (C) Statistics of clinical pregnancy rate during the 2014-2017 fresh embryo transfer cycle. Relative Risk (RR) estimates used to compare probabilities. RR = 0.17, 95% CI = 0.12 – 0.24, P < 0.001. (D) Statistics of live birth rate during the 2014-2017 fresh embryo transfer cycle cycle. RR = 0.12, 95% CI = 0.08 – 0.18, P < 0.001.