Research Paper Volume 12, Issue 4 pp 3962—3975

SOCS1 blocks G1-S transition in hepatocellular carcinoma by reducing the stability of the CyclinD1/CDK4 complex in the nucleus

Figure 3. The effects of SOCS1 overexpression on cell cycle progression. (A) Transcriptome sequencing analysis showed 2552 differentially expressed genes (B, C) KEGG analysis indicated that a variety of cancers and processes relating to cell cycle and ubiquitin regulation were affected by SOCS1. (D) Western blot analysis revealed the effect of SOCS1 on the expression of cyclin proteins and cyclin-dependent kinases.