Research Paper Volume 12, Issue 4 pp 3976—3992

PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

Figure 8. C3k inhibits bone loss and adipogenesis in OVX mice. (A) Micro-CT images of the distal femoral metaphyseal region from the Control, OVX, and OVX + C3k groups. Histograms represent the trabecular structural parameters of the distal femur: bone surface/trabecular bone volume (BS/BV), trabecular bone volume/tissue volume (BV/TV), connectivity density (Conn.D), trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp). (B) H&E staining and Oil Red O staining of distal femoral sections of Control, OVX, and OVX + C3k groups. Scale bar represents 400 μm. Data are presented as means ± SD. n = 10. *P < 0.05 and **P < 0.01.