Research Paper Volume 12, Issue 6 pp 4757—4777

Prognostic value of immune-related genes in the tumor microenvironment of lung adenocarcinoma and lung squamous cell carcinoma

Figure 4. Functional analyses of immune-related prognostic genes. (A, B) PPI networks of the prognostic DEGs determined by the STRING database. The color of each node in the PPI network reflects the log fold-change value of the Z score of gene expression, and the size of the node indicates the number of proteins interacting with the designated protein. (C, E) KEGG analysis of immune-related prognostic genes. Top pathways with P < 0.05 and q value < 0.05 are shown. (D, F) GO analyses of the prognostic DEGs in the categories of biological processes (BP), cellular components (CC), and molecular functions (MF). PPI, Protein-protein interaction, DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.