Research Paper Volume 12, Issue 10 pp 8820—8836

LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway

Figure 8. Schematic representation of H19 in regulating dopaminergic neuron loss in PD. H19 upregulates the expression of HPRT1 by binding to miR-301b-3p. Overexpression of HPRT1 could activate the Wnt/β-catenin signaling pathway, thus promoting the mRNA expression of Nurr-1, Pitx-3, Ngn-2 and NeuroD1 in the substantia nigra tissues, which ultimately rescues the dopaminergic neuron loss in this 6-OHDA-induced PD mouse model.