Online ISSN: 1945-4589

Volume 12, Issue 10

31 May, 2020
pp 8760—10000

About the Cover

The cover features Figure 2 "Factors that increase the fatality risk of COVID-19“ from Mueller et al.


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Table of Contents

Research Perspective

COVID-19
Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19

Javier A. Menendez,
https://doi.org/10.18632/aging.103347 pp 8760—8765
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Priority Research Papers

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice

Xinna Li, Jacquelyn A. Frazier, Edward Spahiu, Madaline McPherson, Richard A. Miller,
https://doi.org/10.18632/aging.103380 pp 8766—8789
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Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

Melod Mehdipour, Colin Skinner, Nathan Wong, Michael Lieb, Chao Liu, Jessy Etienne, Cameron Kato, Dobri Kiprov, Michael J. Conboy, Irina M. Conboy,
https://doi.org/10.18632/aging.103418 pp 8790—8819
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Research Papers

LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway

Jingjing Jiang, Xuanyu Piao, Siying Hu, Jingbo Gao, Min Bao,
https://doi.org/10.18632/aging.102877 pp 8820—8836
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The TβR II-targeted aptamer S58 prevents fibrosis after glaucoma filtration surgery

Xueru Li, Yu Leng, Xiangji Li, Yawei Wang, Peng Luo, Chi Zhang, Ziwen Wang, Xiaofeng Yue, Chongxing Shen, Long Chen, Zujuan Liu, Chunmeng Shi, Lin Xie,
https://doi.org/10.18632/aging.102997 pp 8837—8857
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GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12)

Yuhao Chen, Dian Fu, Hai Zhao, Wen Cheng, Feng Xu,
https://doi.org/10.18632/aging.103005 pp 8858—8879
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lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p

Keqiang Yan, Lifang Hou, Tiantian Liu, Wei Jiao, Qian Ma, Zhiqing Fang, Shimin Zhang, Daoqing Song, Jikai Liu, Xinghua Gao, Yidong Fan,
https://doi.org/10.18632/aging.103007 pp 8880—8892
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Long noncoding RNA lnc-LOC645166 promotes adriamycin resistance via NF-κB/GATA3 axis in breast cancer

Ruinian Zheng, Jun Jia, Ling Guan, Huiling Yuan, Kejun Liu, Chun Liu, Weibiao Ye, Yuting Liao, Shunhuan Lin, Ou Huang,
https://doi.org/10.18632/aging.103012 pp 8893—8912
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HIX003209 promotes vascular smooth muscle cell migration and proliferation through modulating miR-6089

Xiaofeng Shi, Shuang Pan, Li Li, Yongqi Li, Wei Ma, Han Wang, Caiming Xu, Lei Li, Dong Wang,
https://doi.org/10.18632/aging.103079 pp 8913—8922
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Influence of human amylin on the membrane stability of rat primary hippocampal neurons

Nan Zhang, Yuan Xing, Yongzhou Yu, Chao Liu, Baohua Jin, Lifang Huo, Dezhi Kong, Zuxiao Yang, Xiangjian Zhang, Ruimao Zheng, Zhanfeng Jia, Lin Kang, Wei Zhang,
https://doi.org/10.18632/aging.103105 pp 8923—8938
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miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway

Jiaying Tan, Jun Shen, Huigeng Zhu, Ye Gong, Hechen Zhu, Junping Li, Shan Lin, Gang Wu, Tao Sun,
https://doi.org/10.18632/aging.103106 pp 8939—8952
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Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury

Dimin Wang, Kai Wang, Zhenlei Liu, Zonglin Wang, Hao Wu,
https://doi.org/10.18632/aging.103125 pp 8953—8967
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Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair

Yuan Xiong, Lang Chen, Tao Yu, Chenchen Yan, Wu Zhou, Faqi Cao, Xiaomeng You, Yingqi Zhang, Yun Sun, Jing Liu, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi, Guohui Liu,
https://doi.org/10.18632/aging.103143 pp 8968—8986
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in vivo cellular evidence of autophagic associated spermiophagy within the principal cells during sperm storage in epididymis of the turtle

Imran Tarique, Yonghong Shi, Noor Samad Gandahi, Baitao Ding, Ping Yang, Chang Chen, Waseem Ali Vistro, Quisheng Chen,
https://doi.org/10.18632/aging.103144 pp 8987—8999
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The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress

Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming Hu,
https://doi.org/10.18632/aging.103161 pp 9000—9013
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miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension

Li Luo, Lusheng Xiao, Guili Lian, Huajun Wang, Liangdi Xie,
https://doi.org/10.18632/aging.103163 pp 9014—9030
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Role of Citicoline in an in vitro AMD model

Sonali Nashine, M. Cristina Kenney,
https://doi.org/10.18632/aging.103164 pp 9031—9040
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Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

Lile Jiang, Jinquan Cui, Cuilian Zhang, Juanke Xie, Shaodi Zhang, Dongjun Fu, Wei Duo,
https://doi.org/10.18632/aging.103166 pp 9041—9065
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Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway

Chao Zhou, Pu Wang, Lei Lei, Yi Huang, Yue Wu,
https://doi.org/10.18632/aging.103172 pp 9066—9084
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lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

Yanni Yang, Wenlin Tai, Nihong Lu, Ting Li, Yongjun Liu, Wenjuan Wu, Zhengkun Li, Lin Pu, Xiaoyuan Zhao, Tao Zhang, Zhaoxing Dong,
https://doi.org/10.18632/aging.103176 pp 9085—9102
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A novel 3’,5’-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer

Yongqiang Zhang, Jue Yang, Zhonghang Wen, Xiaoyue Chen, Jia Yu, Dongbo Yuan, Bixue Xu, Heng Luo, Jianguo Zhu,
https://doi.org/10.18632/aging.103178 pp 9103—9124
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Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway

Kaishun Zhao, Ran Dong, Yanfang Yu, Chunlin Tu, Ying Li, YuJuan Cui, Lei Bao, Chunhua Ling,
https://doi.org/10.18632/aging.103180 pp 9125—9138
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Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization

Jing Lv, Jin Chen, Minjia Wang, Fei Yan,
https://doi.org/10.18632/aging.103183 pp 9139—9150
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Downregulation of miRNA-146a-5p promotes malignant transformation of mesenchymal stromal/stem cells by glioma stem-like cells

Xingliang Dai, Yunfei Wang, Xuchen Dong, Minfeng Sheng, Haiyang Wang, Jia Shi, Yujing Sheng, Liang Liu, Qianqian Jiang, Yanming Chen, Bingshan Wu, Xuejun Yang, Hongwei Cheng, Chunsheng Kang, Jun Dong,
https://doi.org/10.18632/aging.103185 pp 9151—9172
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Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet

Yawen Zhang, Luyi Chen, Mengjia Hu, John J. Kim, Renbin Lin, Jilei Xu, Lina Fan, Yadong Qi, Lan Wang, Weili Liu, Yanyong Deng, Jianmin Si, Shujie Chen,
https://doi.org/10.18632/aging.103187 pp 9173—9187
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A three-lncRNA signature predicts clinical outcomes in low-grade glioma patients after radiotherapy

Wanzun Lin, Zongwei Huang, Yanyan Xu, Xiaochuan Chen, Ting Chen, Yuling Ye, Jianming Ding, Zhangjie Chen, Long Chen, Xianxin Qiu, Sufang Qiu,
https://doi.org/10.18632/aging.103189 pp 9188—9204
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Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma

Shen-Nan Shi, Xia Qin, Shuo Wang, Wen-Fu Wang, Yao-Feng Zhu, Yu Lin, Zun-Lin Zhou, Ben-Kang Shi, Xi-Gao Liu,
https://doi.org/10.18632/aging.103192 pp 9205—9223
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Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways

Ting-Kuo Chang, Yu-Han Wang, Shu-Jui Kuo, Shih-Wei Wang, Chun-Hao Tsai, Yi-Chin Fong, Nan-Lin Wu, Shan-Chi Liu, Chih-Hsin Tang,
https://doi.org/10.18632/aging.103195 pp 9224—9239
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BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake

Hui Wang, Haiping Fu, Ruigong Zhu, Xuan Wu, Xian Ji, Xuesong Li, Hong Jiang, Zhe Lin, Xin Tang, Shixiu Sun, Jiajing Chen, Xin Wang, Qingguo Li, Yong Ji, Hongshan Chen,
https://doi.org/10.18632/aging.103200 pp 9240—9259
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Integrative analysis of genomic and epigenetic regulation of endometrial cancer

Qihang Zhong, Junpeng Fan, Honglei Chu, Mujia Pang, Junsheng Li, Yong Fan, Ping Liu, Congying Wu, Jie Qiao, Rong Li, Jing Hang,
https://doi.org/10.18632/aging.103202 pp 9260—9274
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NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells

Min Gao, Alice Laschuk Herlinger, Renchin Wu, Tian-Li Wang, Ie-Ming Shih, Beihua Kong, Leticia Batista Azevedo Rangel, Jin-Ming Yang,
https://doi.org/10.18632/aging.103203 pp 9275—9291
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PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

Zhengyan Chang, Guo Ji, Runzhi Huang, Hong Chen, Yaohui Gao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, Qing Wei,
https://doi.org/10.18632/aging.103206 pp 9292—9310
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Single nucleotide polymorphisms within the Wnt pathway predict the risk of bone metastasis in patients with non-small cell lung cancer

Yiquan Xu, Hongru Li, Lihong Weng, Yanqin Qiu, Junqiong Zheng, Huaqiang He, Dongmei Zheng, Junfan Pan, Fan Wu, Yusheng Chen,
https://doi.org/10.18632/aging.103207 pp 9311—9327
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Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes

Guoxing Tang, Xu Yuan, Ying Luo, Qun Lin, Zhishui Chen, Xue Xing, Huijuan Song, Shiji Wu, Hongyan Hou, Jing Yu, Liyan Mao, Weiyong Liu, Feng Wang, Ziyong Sun,
https://doi.org/10.18632/aging.103208 pp 9328—9343
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Body mass index across adult life and cognitive function in the American elderly

Yun Zhou, Tao Zhang, Daniel Lee, Lin Yang, Shengxu Li,
https://doi.org/10.18632/aging.103209 pp 9344—9353
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Efficacies of different ovarian hyperstimulation protocols in poor ovarian responders classified by the POSEIDON criteria

Fei Li, Tian Ye, Huijuan Kong, Jing Li, Linli Hu, HaiXia Jin, Yingchun Su, Gang Li,
https://doi.org/10.18632/aging.103210 pp 9354—9364
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Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer’s disease

Mei Xue, Fu-Rong Sun, Ya-Nan Ou, Xue-Ning Shen, Hong-Qi Li, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative,
https://doi.org/10.18632/aging.103211 pp 9365—9379
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Prognostic value of microRNAs in pancreatic cancer: a meta-analysis

Fei Zhao, Chao Wei, Meng-Ying Cui, Qiang-Qiang Xia, Shuai-Bin Wang, Yue Zhang,
https://doi.org/10.18632/aging.103214 pp 9380—9404
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Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Xue Zhang, Yiming Zhang, Rui Li, Lingpeng Zhu, Buqing Fu, Tianhua Yan,
https://doi.org/10.18632/aging.103215 pp 9405—9426
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Development of a nomogram that predicts the risk for coronary atherosclerotic heart disease

Shuna Huang, Xiaoxu Xie, Yi Sun, Tingxing Zhang, Yingying Cai, Xingyan Xu, Huangyuan Li, Siying Wu,
https://doi.org/10.18632/aging.103216 pp 9427—9439
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Effects of passive smoking and its duration on the prevalence of prediabetes and type 2 diabetes mellitus in Chinese women

Juan Wu, Gui Pan, Yan-Ting Huang, Deng-Ke Liu, Hai-Xia Zeng, Xiao-Jun Zhou, Xiao-Yang Lai, Jian-Ping Liu,
https://doi.org/10.18632/aging.103217 pp 9440—9446
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Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

Donald A. Lamb, Johnathon H. Moore, Paulo Henrique Caldeira Mesquita, Morgan A. Smith, Christopher G. Vann, Shelby C. Osburn, Carlton D. Fox, Hector L. Lopez, Tim N. Ziegenfuss, Kevin W. Huggins, Michael D. Goodlett, Andrew D. Fruge, Andreas N. Kavazis, Kaelin C. Young, Michael D. Roberts,
https://doi.org/10.18632/aging.103218 pp 9447—9460
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Regulation of PGC-1α mediated by acetylation and phosphorylation in MPP+ induced cell model of Parkinson’s disease

Fei Fan, Songlin Li, Zhipeng Wen, Qiaoyue Ye, Xiaochun Chen, Qinyong Ye,
https://doi.org/10.18632/aging.103219 pp 9461—9474
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Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma

Yu-Wen Huang, Chih-Yang Lin, Hsiao-Chi Tsai, Yi-Chin Fong, Chien-Kuo Han, Yuan-Li Huang, Wen-Tung Wu, Shih-Ping Cheng, Hao-Chiun Chang, Kuang-Wen Liao, Shih-Wei Wang, Chih-Hsin Tang,
https://doi.org/10.18632/aging.103220 pp 9475—9488
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PI3K-Akt-mTOR inhibition by GNE-477 inhibits renal cell carcinoma cell growth in vitro and in vivo

Xueting Ye, Jian-Wei Ruan, Hang Huang, Wei-Ping Huang, Yan Zhang, Fangyi Zhang,
https://doi.org/10.18632/aging.103221 pp 9489—9499
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MiR-16-5p regulates postmenopausal osteoporosis by directly targeting VEGFA

Tao Yu, Xiaomeng You, Haichao Zhou, Wenbao He, Zihua Li, Bing Li, Jiang Xia, Hui Zhu, Youguang Zhao, Guangrong Yu, Yuan Xiong, Yunfeng Yang,
https://doi.org/10.18632/aging.103223 pp 9500—9514
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Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

Liangqin Shi, Chao Huang, Qihui Luo, Yu Xia, Wentao Liu, Wen Zeng, Anchun Cheng, Riyi Shi, Chen Zhengli,
https://doi.org/10.18632/aging.103225 pp 9515—9533
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Dexmedetomidine inhibits LPS-induced proinflammatory responses via suppressing HIF1α-dependent glycolysis in macrophages

Qingyuan Meng, Pinhao Guo, Zhengyu Jiang, Lulong Bo, Jinjun Bian,
https://doi.org/10.18632/aging.103226 pp 9534—9548
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MiR-1908/EXO1 and MiR-203a/FOS, regulated by scd1, are associated with fracture risk and bone health in postmenopausal diabetic women

Yi-sheng Chen, Xue-ran Kang, Zi-hui Zhou, Jiang Yang, Qi Xin, Chen-ting Ying, Yun-peng Zhang, Jie Tao,
https://doi.org/10.18632/aging.103227 pp 9549—9584
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Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway

Le Li, Bin Wu, Qiangqiang Zhao, Jian Li, Yunfeng Han, Xiaohang Fan, Junli Dong, Pengcheng Li,
https://doi.org/10.18632/aging.103228 pp 9585—9603
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KMT2A regulates cervical cancer cell growth through targeting VDAC1

Changlin Zhang, Yijun Hua, Huijuan Qiu, Tianze Liu, Qian Long, Wei Liao, Jiehong Qiu, Nang Wang, Miao Chen, Dingbo Shi, Yue Yan, Chuanbo Xie, Wuguo Deng, Tian Li, Yizhuo Li,
https://doi.org/10.18632/aging.103229 pp 9604—9620
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Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2

Danping Wang, Zhi Nie, Xiaoyan Jiang, Jinxiang Ye, Zhimin Wei, Dating Cheng, Chenyang Wang, Yingying Wu, Rong Liu, Haijun Chen, Ceshi Chen, Chunyan Wang,
https://doi.org/10.18632/aging.103232 pp 9621—9632
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MicroRNA-214-3p targets the PLAGL2-MYH9 axis to suppress tumor proliferation and metastasis in human colorectal cancer

Zili Zhou, Liang Wu, Zhengyi Liu, Xudan Zhang, Shengbo Han, Ning Zhao, Haijun Bao, Wenzheng Yuan, Jinhuang Chen, Jintong Ji, Xiaogang Shu,
https://doi.org/10.18632/aging.103233 pp 9633—9657
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Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer

Danian Dai, Bo Chen, Yanling Feng, Weizhong Wang, Yanhui Jiang, He Huang, Jihong Liu,
https://doi.org/10.18632/aging.103235 pp 9658—9685
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Ovulation and ovarian wound healing are impaired with advanced reproductive age

Jamie N. Mara, Luhan T. Zhou, Megan Larmore, Brian Johnson, Rebecca Ayiku, Farners Amargant, Michele T. Pritchard, Francesca E. Duncan,
https://doi.org/10.18632/aging.103237 pp 9686—9713
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Qigesan inhibits esophageal cancer cell invasion and migration by inhibiting Gas6/Axl-induced epithelial-mesenchymal transition

Lingyu Kong, Xin Lu, Xuanyu Chen, Yunyan Wu, Yushuang Zhang, Huijuan Shi, Jing Li,
https://doi.org/10.18632/aging.103238 pp 9714—9725
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NF2 deficiency accelerates neointima hyperplasia following vascular injury via promoting YAP-TEAD1 interaction in vascular smooth muscle cells

Xiongshan Sun, Shuang Li, Xueqing Gan, Ken Chen, Dachun Yang, Yongjian Yang,
https://doi.org/10.18632/aging.103240 pp 9726—9744
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Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells

Sebastiano Giallongo, Michelino Di Rosa, Rosario Caltabiano, Lucia Longhitano, Michele Reibaldi, Alfio Distefano, Oriana Lo Re, Angela Maria Amorini, Lidia Puzzo, Lucia Salvatorelli, Stefano Palmucci, Daniele Tibullo, Andrea Russo, Antonio Longo, Giacomo Lazzarino, Giovanni Li Volti, Manlio Vinciguerra,
https://doi.org/10.18632/aging.103241 pp 9745—9760
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Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

Mert Icyuz, Michael Fitch, Fang Zhang, Anil Challa, Liou Y. Sun,
https://doi.org/10.18632/aging.103242 pp 9761—9780
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LncRNA DSCAM-AS1 promotes colorectal cancer progression by acting as a molecular sponge of miR-384 to modulate AKT3 expression

Bo Li, Hai Sun, Jiayu Zhang,
https://doi.org/10.18632/aging.103243 pp 9781—9792
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Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis

Yong Wang, Rongfen Gao, Jinpeng Li, Shaotao Tang, Shuai Li, Qiangsong Tong, Yongzhong Mao,
https://doi.org/10.18632/aging.103244 pp 9793—9806
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Identification and validation of hub microRNAs dysregulated in esophageal squamous cell carcinoma

Chen Sang, Ce Chao, Min Wang, Youpu Zhang, Guanghua Luo, Xiaoying Zhang,
https://doi.org/10.18632/aging.103245 pp 9807—9824
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Association between metabolic syndrome and endometrial cancer risk: a systematic review and meta-analysis of observational studies

Lan Wang, Zhen-Hua Du, Jia-Ming Qiao, Song Gao,
https://doi.org/10.18632/aging.103247 pp 9825—9839
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Development of a machine learning-based multimode diagnosis system for lung cancer

Shuyin Duan, Huimin Cao, Hong Liu, Lijun Miao, Jing Wang, Xiaolei Zhou, Wei Wang, Pingzhao Hu, Lingbo Qu, Yongjun Wu,
https://doi.org/10.18632/aging.103249 pp 9840—9854
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Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke

Rong-Hua Hong, Jian Zhu, Ze-Zhi Li, Jian Yuan, Pei Zhao, Jie Ding, Qing-Lei Fan, Jin Yang, Bao-Guo Liu, Jian Cai, De-Sheng Zhu, Yang-tai Guan,
https://doi.org/10.18632/aging.103250 pp 9855—9867
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Construction of immune-related and prognostic lncRNA clusters and identification of their immune and genomic alterations characteristics in lung adenocarcinoma samples

Jia Li, Chenyue Zhang, Chenxing Zhang, Haiyong Wang,
https://doi.org/10.18632/aging.103251 pp 9868—9881
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Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases

Wen-Xing Li, Gong-Hua Li, Xin Tong, Peng-Peng Yang, Jing-Fei Huang, Lin Xu, Shao-Xing Dai,
https://doi.org/10.18632/aging.103253 pp 9882—9914
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ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer

Jie Yao, Kaiyu Qian, Chen Chen, Xiaoping Liu, Donghu Yu, Xin Yan, Tongzu Liu, Sheng Li,
https://doi.org/10.18632/aging.103256 pp 9915—9934
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Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1

Yu Ikemoto, Toshiyuki Miyashita, Michiyo Nasu, Hiromi Hatsuse, Kazuhiro Kajiwara, Katsunori Fujii, Toshino Motojima, Ibuki Kokido, Masashi Toyoda, Akihiro Umezawa,
https://doi.org/10.18632/aging.103258 pp 9935—9947
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Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway

Kaiwen Li, Shirong Peng, Zean Li, Yiming Lai, Qiong Wang, Yiran Tao, Wanhua Wu, Qianghua Zhou, Ze Gao, Junxiu Chen, Hui Li, Wenli Cai, Zhenghui Guo, Hai Huang,
https://doi.org/10.18632/aging.103260 pp 9948—9958
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Reviews

COVID-19
Why does COVID-19 disproportionately affect older people?

Amber L. Mueller, Maeve S. McNamara, David A. Sinclair,
https://doi.org/10.18632/aging.103344 pp 9959—9981
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Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models

María Álvarez-Satta, Alejandro Berna-Erro, Estefania Carrasco-Garcia, Ainhoa Alberro, Ander Saenz-Antoñanzas, Itziar Vergara, David Otaegui, Ander Matheu,
https://doi.org/10.18632/aging.103295 pp 9982—9999
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Correction

Correction for: Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise

Vagner Ramon Rodrigues Silva, Carlos Kiyoshi Katashima, Carla G. Bueno Silva, Luciene Lenhare, Thayana Oliveira Micheletti, Rafael Ludemann Camargo, Ana Carolina Ghezzi, Juliana Alves Camargo, Alexandre Moura Assis, Natalia Tobar, Joseane Morari, Daniela S. Razolli, Leandro Pereira Moura, José Rodrigo Pauli, Dennys Esper Cintra, Lício Augusto Velloso, Mario J.A. Saad, Eduardo Rochete Ropelle,
https://doi.org/10.18632/aging.103194 pp 10000
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