Research Paper Volume 12, Issue 5 pp 4247—4267

Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling

Figure 1. Dynamic changes in hypoxic lung injury-related indicators. (A) H&E staining of rat lung tissue. Magnifications of the same section (200X and 400X) are shown. (B) Analysis of arterial blood gasses. (C, D) Measurements of total protein concentration in BALF and lung tissue W/D. (E) Immunohistochemical staining of occludin in rat lung tissue (400X). (F) ELISA analysis of IL-6 and TNF-α levels in serum and BALF. Data are mean ± SEM. **P < 0.01 compared with the normoxic control group; #P < 0.05, ##P < 0.01 compared with the 24-h hypoxia group; &P < 0.05, &&P < 0.01 compared with the 48-h hypoxia group.