NMDA receptor blockade rescues BCAL induced network synchronization but not microcircuit dysfunction. (A) Raster plots depicting changes in activity (ΔF/F) over time for a representative correlation matrices quantifying network synchronization between each spine and every other (B) Representative correlation matrices quantifying functional connectivity between each spine and every other spine. (C, D) The in network synchronization and mean spine-spine correlation on the 3rd day after reperfusion. n= 1044 spines in 6 Reper mice, n= 824 spines in 4 Ro25-6981-treated mice. **P < 0.01, two-way ANOVA with Bonferroni correction. Error bars = s.e.m.