Research Paper Volume 12, Issue 5 pp 4299—4321

Transient ischemia-reperfusion induces cortical hyperactivity and AMPAR trafficking in the somatosensory cortex

Figure 6. Ro25-6981 rescues the changes in spine sGluA1 with shaft sGluA1 and spine size following BCAL. (AC) Correlation between spine sGluA1 intensity and spine structure intensity at the 3rd hour (A), on the first day (B) and the 3rd day (C) of ischemia-reperfusion in control, Reper and Ro25-6981-treated mice. (DF) Correlation between spine sGluA1 intensity and shaft sGluA1 intensity at the 3rd hour (D), on the first day (E) and the 3rd day (F) of ischemia-reperfusion in control, Reper and Ro25-6981-treated mice. (GI) Correlation between shaft sGluA1 intensity and spine structure intensity at the 3rd hour (G), on the first day (H) and the 3rd day (I) of ischemia-reperfusion in control, Reper and Ro25-6981-treated mice. The 3rd hour n= 342 spines in 5 control mice, n= 418 spines in Reper mice, and n= 457 spines in 5 Ro25-6981-treated mice. The first day n= 425 spines in 5 control mice, n= 379 spines in Reper mice, and n= 411 spines in 5 Ro25-6981-treated mice. The 3rd day n= 410 spines in 5 control mice, n=283 spines in Reper mice, n= 274 spines in 5 Ro25-6981-treated mice. r, Pearson's linear correlation coefficient. p, Pearson's correlation t test.