Research Paper Volume 12, Issue 5 pp 4407—4423

Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer’s disease


Figure 1. Associations between telomere length (TL) and baseline cognitive function in each Alzheimer’s disease (AD) cognitive stage group. Simple linear regression was performed with TL as independent variable and each cognitive function test as dependent variable. (A) Significant positive association between TL and Mini-Mental State Examination (MMSE) scores in the cognitively unimpaired (CU) A+ group (R2 = 0.190). (B) Significant positive association between TL and Consortium to Establish a Registry for AD (CERAD) scores in the AD dementia (ADD) A+ group (R2 = 0.152). (C) No significant association was detected between TL and Clinical Dementia Rating-Sum of Boxes (CDR-SB) in each AD cognitive stage group. (D) Significant positive association between TL and Logical Memory delayed recall scores in the mild cognitive impairment (MCI) A+ group (R2 = 0.245). Higher scores suggest better cognition in MMSE, CERAD, and LM delayed recall test, and lower scores suggest better performance in CDR-SB.