Research Paper Volume 12, Issue 5 pp 4407—4423

Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer’s disease

Figure 3. Conversion from mild cognitive impairment (MCI) to dementia according to the telomere length (TL) quartile groups in MCI A+. Normalized cumulative conversion data are based on Cox proportional hazards regression analysis adjusted for age as a covariate. The lowest TL quartile group (TL ≤ 6.61 kb) had a significantly greater probability of progressing to dementia compared with the highest TL quartile group (TL > 7.85 kb) in the MCI A+ participants (hazard ratio = 13.16, 95% confidence interval = 1.11 ~ 156.61, P = 0.041).