Research Paper Volume 12, Issue 5 pp 4407—4423

Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer’s disease

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Figure 3. Conversion from mild cognitive impairment (MCI) to dementia according to the telomere length (TL) quartile groups in MCI A+. Normalized cumulative conversion data are based on Cox proportional hazards regression analysis adjusted for age as a covariate. The lowest TL quartile group (TL ≤ 6.61 kb) had a significantly greater probability of progressing to dementia compared with the highest TL quartile group (TL > 7.85 kb) in the MCI A+ participants (hazard ratio = 13.16, 95% confidence interval = 1.11 ~ 156.61, P = 0.041).