Priority Research Paper Volume 12, Issue 5 pp 4052—4066

Survey of senescent cell markers with age in human tissues

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Figure 5. Intestine (colon). (A, B) Cells expressing p16 (A) or p21 (B) were identified by IHC staining in the colon of Young, Middle-aged, and Old donors. (C) p16-expressing cells in colon shown at lower magnification (20x). Graphs represent the quantification (%) of p16-positive (A) and p21-positive (B) cells from 5 tissue cores from independent donors per organ and age group; data represent the means ±SD from 5 different donors. p values were determined by one-way ANOVA with Tukey adjustments for multiple comparisons where appropriate. *, p < 0.05.