Research Paper Volume 12, Issue 6 pp 4836—4865

Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder

Figure 1. Effects of Nrf2 deficiency on physiological changes, lung and heart injuries in PM2.5-exposed mice. (A) The change of body weight of mice during treatment. n = 15 in each group. (B) Calculation of blood glucose. n = 15 in each group. (C) MBP of mice from week 1 to week 24. n = 15 in each group. (D) H&E staining of lung tissue (up panel) and heart tissue (down panel) sections. n = 6 in each group. Scale bar was 200 μm for the images in the up panels of lung and heart. (E) Total cell number and (F) protein concentrations in BALF were measured. n = 8 in each group. (G) Serum CK and (H) LDH levels were determined. n = 8 in each group. Data were expressed as the mean ± SEM. *P < 0.05 and **P < 0.01.