Research Paper Volume 12, Issue 5 pp 4527—4546

LncRNA-LALR1 upregulates small nucleolar RNA SNORD72 to promote growth and invasion of hepatocellular carcinoma

Figure 2. Knock-down of lncRNA-LALR1 suppresses growth and invasion of HCC cells in vitro. (A) CCK-8 assay showing knockdown of lncRNA-LALR1 decreases the proliferation ability compared with control group of SMMC-7721 cells. (B) Colony formation assay showing lncRNA-LALR1 knockdown reduces the growth ability compared with control group of SMMC-7721 cells. (C) Colony formation assay showing lncRNA-LALR1 knockdown reduces the growth ability compared with control group of SMMC-7721 cells. (D) CCK-8 assay showing knockdown of lncRNA-LALR1 decreases the proliferation ability compared with control group of HepG2 cells. (E) Colony formation assay showing lncRNA-LALR1 knockdown reduces the growth ability compared with control group of HepG2 cells. (F) Colony formation assay showing lncRNA-LALR1 knockdown reduces the growth ability compared with control group of HepG2 cells. (G) Western Blot assay showing knockdown of lncRNA-LALR1 downregulates cyclinD1, cyclinE1, MMP-2 and MMP-9. (H) Transwell invasion assay showing lncRNA-LALR1 silencing decreases the invasion ability compared with control group of SMMC-7721 cells. (I) Transwell invasion assay showing lncRNA-LALR1 silencing decreases the invasion ability compared with control group of HepG2 cells. *: P < 0.05; **: P < 0.01; ***: P < 0.001.