Research Paper Volume 12, Issue 6 pp 4866—4878

MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer

Figure 7. MiR-519d suppresses PI3K/AKT pathway via targeting HER3. Western blot analyses (A) and statistical analysis (B) demonstrated that the overexpression of miR-519d significantly inhibited the phosphorylation of PI3K and AKT. (C) Suppression of miR-519d enhanced the phosphorylation of PI3K and AKT, but these effects could largely be reversed by silencing HER3. (D) Statistical analysis. *p<0.05 vs. control, **p<0.01 vs. control, ***p<0.001 vs. control.