Research Paper Volume 12, Issue 5 pp 4573—4591

APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma

Figure 10. High APEX1 expression positively correlates with DNA damage repair in HCC patients. (A) The top ten signaling pathways in HCC tissues based on gene set enrichment analysis (GSEA) are shown. (B) Enrichment plot shows the status of DNA damage repair pathways in HCC and adjacent normal liver tissue samples. (C) The most significant survival-associated genes in the HCC tissues according to analysis using the GEPIA portal and the most enriched genes in HCC tissues based on the gene ontology (GO) analysis are shown. The right panel shows the top four prognosis-related pathways that are enriched in the HCC tissues. (D) The median mRNA levels of genes that co-express with APEX1 in HCC tissues are shown. (E, F) The enrichment plot shows GSEA analysis of genes involved in DNA conformation change and DNA damage repair in the HCC tissues.