Figure 8. The change of neuroactive ligand-receptors in MCT-induced PAH. (A) Hierarchical clustering of DEGs that were annotated in the cholinergic and adrenergic receptors as well as GABA receptors. (B–D) Temporal expression levels of DEGs annotated in neuroactive ligand-receptor interaction. Data were shown as mean ± S.E.M and analyzed by one-way ANOVA followed by Dunnett’s test, n = 3 MCT-treated rats at each week, and n = 5 control. *p<0.05 vs control and **p<0.01 vs control.