Research Paper Volume 12, Issue 6 pp 4970—4995

Integrative analysis of DNA methylation and gene expression reveals distinct hepatocellular carcinoma subtypes with therapeutic implications

Figure 2. Correlation of our classification (HS1, HS2, HS3 and HS4) with distinct clinical characteristics and previously published HCC subclasses. Prediction of previously published HCC classifications was performed with NTP analyses. Statistical significance of differences was determined by Chi-square test (ns represents no significance, * represents P < 0.05, ** represent P < 0.01, *** represent P < 0.001, **** represent P < 0.0001). HCC: hepatocellular carcinoma; NTP: Nearest Template Prediction.