Research Paper Volume 12, Issue 6 pp 4970—4995

Integrative analysis of DNA methylation and gene expression reveals distinct hepatocellular carcinoma subtypes with therapeutic implications

Figure 4. Difference of progression-relevant signatures among HCC subclasses. (A) Heatmap of progression-relevant signatures in 4 HCC subclasses. (B) Box plots (from 25th percentile to the 75th percentile with a line at the median) show the abundance of progression-associated signatures. Statistical significance of overall differences was determined by Kruskal Wallis test (ns represents no significance, * represents P < 0.05, ** represent P < 0.01, *** represent P < 0.001, **** represent P < 0.0001).