Research Paper Volume 12, Issue 6 pp 5048—5070

Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma

Figure 3. An 8-mRNA signature system was established to predict the overall survival of PAAD patients. (A) LASSO coefficient profiles of 14 mRNA with P<0.01. (B) 10-fold cross-validations result which identified optimal values of the penalty parameter λ. (C) The association between each gene and overall survival. (D, E) The Kaplan-Meier curves in the training set (D) and the validation set (E). (F, G) Time-dependent ROC analysis at 1, 2 and 3 years in the training set (F) and the validation set (G).