Research Paper Volume 12, Issue 6 pp 5121—5139

EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke

Figure 4. Matrix metalloproteinase-9 (MMP-9) protein concentrations and infarct volumes decrease following anti-CD147 antibody administration. (A) Timeline depicting the dosing strategy of CD147. (B) Representative western blots of MMP-9 protein concentrations in 72-hour post stroke mice following IgG control or anti-CD147 antibody administration, quantified in (C) p<0.01, n=4, * indicates statistical significance. (D) Representative TTC images of 72 hour post stroke brain slices of IgG control or ant-CD147 antibody. Red color details healthy brain tissue while white is indicative of infarcted tissue. (E) Quantification of percent infarct volume of cortex, striatum or total hemisphere relative to contralateral regions, p<0.05 for each region, n=4.