Research Paper Volume 12, Issue 6 pp 5121—5139

EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke

Figure 8. CD147 is expressed on human astrocytes and levels of CD147 correlate with poor outcomes. (A) Serum levels of human CD147 24 hours post stroke. (B) Representative immunohistochemical staining patterns of CD147 in human brain tissues from age-matched control and ischemic stroke subjects (Top, scale bar = 50 μm). Immunofluorescence (IF) staining in human brain tissues (Bottom, scale bar = 100 μm). Simple IF with DAPI (blue), CD147 (green), and GFAP (red). Double IF with CD147 (green) and GFAP (red). (C) Quantification of levels of CD147 and GFAP expressing CD147 in human brain tissue.