Research Paper Volume 12, Issue 6 pp 5183—5194

LncRNA AGAP2-AS1 augments cell viability and mobility, and confers gemcitabine resistance by inhibiting miR-497 in colorectal cancer

Figure 2. AGAP2-AS1 promoted cell viability both in vitro and in vivo. (A) Relative expression of AGAP2-AS1 in CRC cell lines. (B) Validation of overexpression and knockdown efficacy of AGAP2-AS1 in CRC cell lines by qRT-PCR. (C, D) Effects of AGAP2-AS1 overexpression and downregulation on CRC cell proliferation were measured by CCK-8 assay. (E) Effects of AGAP2-AS1 on colony formation in CRC cells. (F) AGAP2-AS1 overexpression promoted CRC tumorigenesis in a xenograft mouse model. *P < 0.05; **P < 0.01.