Research Paper Volume 12, Issue 6 pp 5259—5279

Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer

Figure 6. Identification of potential targets of hsa-miR-145-5p and hsa-miR-135b-5p in colorectal cancer. (A) The volcano plot of differentially expressed genes (DEGs) in colorectal cancer from GSE126092 dataset. The red dots and green dots represent upregulated DEGs and downregulated DEGs with significance (adjust P-value < 0.05 and |log2FC| > 1), respectively. The black dots are those DEGs without significance. (B) The intersection analysis of target genes of downregulated hsa-miR-145-5p and upregulated DEGs. (C) The intersection analysis of target genes of upregulated hsa-miR-135b-5p and downregulated DEGs. (D) Validation of expression of 17 potential upregulated DEGs using starBase. (E) Validation of expression of 10 potential downregulated DEGs using starBase. “p<0.05” represents significant difference.