Research Paper Volume 12, Issue 6 pp 5280—5299

m6A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway

Figure 7. The MALAT1/miR-145/FAK axis is involved in the mechanism of fibrosis treatment drugs. (A) Western blot analyses of E-cad, α-SMA and GAPDH expression in HK2 cells receiving different treatments. (B and C) CCK8, EdU and cell migration analyses of the viability, proliferation and migration of HK2 cells receiving different treatments. (DF) qRT-PCR analyses of the expression profile of the MALAT1/miR-145/FAK axis in HK2 cells receiving different treatments. GAPDH was used as a control. *P < 0.05 and **P < 0.01. (GI) qPCR analysis of MALAT1, miR-145 and FAK expressions in sham group, UUO models and UUO models receiving DHA treatment.