Research Paper Volume 12, Issue 6 pp 5300—5317

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

Figure 4. Verapamil extends lifespan by inhibiting the activity of calcineurin. (A) Verapamil (100 μM) reduced the activity of calcineurin in C. elegans (***P < 0.001). Cyclosporin A (CsA) was used as positive control (***P < 0.001). An unpaired t-test was used to calculate the P-values and error bars represent SEM. (B) Verapamil (100 μM) did not extend the lifespan of worms treated with tax-6 RNAi. The log-rank (Mantel-Cox) test was used to assess the P-values.