Research Paper Volume 12, Issue 6 pp 5300—5317

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

Figure 6. Verapamil facilitates autophagy downstream of calcineurin in C. RNAi induced autophagy in worms expressing GFP::LGG-1 (****P < 0.0001); however, verapamil (100 μM) did not facilitate autophagy under tax-6 RNAi treatment. An unpaired t-test was used to calculate the P-values and error bars represent SEM.