Research Paper Volume 12, Issue 6 pp 5300—5317

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

Figure 6. Verapamil facilitates autophagy downstream of calcineurin in C. elegans.tax-6 RNAi induced autophagy in worms expressing GFP::LGG-1 (****P < 0.0001); however, verapamil (100 μM) did not facilitate autophagy under tax-6 RNAi treatment. An unpaired t-test was used to calculate the P-values and error bars represent SEM.