Research Paper Volume 12, Issue 6 pp 5469—5478

Intranasal delivery of 9-cis retinoic acid reduces beta-amyloid deposition via inhibiting astrocyte-mediated inflammation

Figure 1. Treatment with 9-cis RA reduced the level of Αβ deposition in APP/PS1 mice compared with vehicle-treated control mice. (A) Representative images of Αβ staining in the frontal cortex and hippocampus of APP/PS1 mice treated with vehicle as a control (left) or 9-cis RA (right). Scale bars, 500 μm. (B) Stereological quantification of the Αβ volume in the cortex (left) and hippocampus (right). (C) Stereological quantification of the Αβ numbers in the cortex (left) and hippocampus (right). Values from multiple images of each section that cover most of the region of study were averaged per animal per experiment. Data represent the mean ± SEM (n=6). **, p<0.01.