Research Paper Volume 12, Issue 6 pp 5469—5478

Intranasal delivery of 9-cis retinoic acid reduces beta-amyloid deposition via inhibiting astrocyte-mediated inflammation

Figure 3. 9-cis RA suppressed the activation of astrocytes in APP/PS1 mice. (A) Representative images of GFAP and 82E1 immunochemistry in coronal sections from 7-month-old APP/PS1 animals treated with 9-cis RA (bottom) or vehicle (upper). (B) Quantification of amyloid-associated astrocyte processes compared with the Ctrl (vehicle). (C) Quantification of amyloid-associated astrocyte bodies compared with the Ctrl (vehicle). Scale bars, 50 μm. Data represent the mean ± SEM (n=6). **, p<0.01.