Research Paper Volume 12, Issue 10 pp 8837—8857

The TβR II-targeted aptamer S58 prevents fibrosis after glaucoma filtration surgery

Figure 1. Determination of the interaction between TβR II and S58. (A) Hydrophobic surface properties between TβR II and S58. (B) Binding sequence between TβR II and S58. (C) The TβR II and S58 interaction regions. (D) Conformation superposition of crystalline TβR II, TGF-β2 and S58. (E) Representative images showing immunofluorescence staining for S58 targets TβR II receptor (nuclei stained blue, FITC-S58 stained green). (F) HConFs were pretreated by TGF-β2 with or without in the presence of S58 and were transfected with or without siRNA-TβR II for 72. (G) Protein levels of α-SMA, TβR II and p-smad2/3 were determined. GAPDH was used as loading control.