Research Paper Volume 12, Issue 9 pp 7660—7678

HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson’s disease by elevating NPTX2 via miR-221-3p binding

Figure 7. A mechanism map depicting the role of the HOTAIR/miR-221-3p/NPTX2 axis in PD. Inhibition of HOTAIR expression reduces autophagy of dopaminergic neurons through miR-221-3p-mediated down-regulation of NPTX2, thus retarding the onset and progression of PD.