Priority Research Paper Volume 12, Issue 7 pp 5612—5624

Supraphysiological protection from replication stress does not extend mammalian lifespan

Figure 2. Chk1 and Rrm2 transgenes do not affect mouse lifespan. (A) Kaplan-Meier survival curves for WT (n=26), Chk1Tg (n=34), Rrm2Tg (n=42) and Chk1Tg;Rrm2Tg (n=33) mice. P-value = 0.3944 using the log-rank test; (B) Hematoxylin and eosin staining of mouse spleen, liver and kidney for mice with the indicated genotypes. Scale bar indicates 60 μm; (C) Total body weight of mice at one year of age. P-values were calculated using the unpaired t-test.