Research Paper Volume 12, Issue 9 pp 7717—7728

Resveratrol attenuates doxorubicin-induced meiotic failure through inhibiting oxidative stress and apoptosis in mouse oocytes

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Figure 1. Effect of different concentrations of DXR and RES on oocyte meiotic maturation. (A) Microscopy images of oocytes morphologies in control, DXR treatment and RES-supplemented group, oocytes exhibited bigger first polar body (black arrowhead) after DXR treatment. Bar = 200 μm. (B) The oocyte maturation rate was recorded in control and DXR treatment groups. (C) Effect of different concentrations of RES on oocyte maturation in DXR-treated oocytes. The number of oocytes used was shown above the according column. (D) The rate of abnormal meiosis was recorded in control, DXR and RES-supplemented oocytes. All experiments were repeated at least 3 times with more than 30 oocytes examined for each experimental condition. Results were represented as means ± SEMs. * means P < 0.05, **means P < 0.01, *** means P < 0.001.