Research Paper Volume 13, Issue 8 pp 12179—12193

circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene

circRNA

Figure 1. circRNA_141539 was up-regulated in ESCC tissue. (A) Hierarchical clustering analysis showed the top 10 most up-regulated and down-regulated circRNAs. The expression levels are presented in different colors indicating expression levels. (B, C) qRT-PCR assay showed that circRNA_001937 was significantly up-regulated in ESCC tissues (n=50), *P < 0.05, **P < 0.01 versus corresponding adjacent tissues. circRNA_141539 expression levels were normalized to GAPDH. N: adjacent normal tissues, C: ESCC tissues.