Research Paper Volume 12, Issue 9 pp 7729—7746

Long noncoding RNA LINC00324 promotes retinoblastoma progression by acting as a competing endogenous RNA for microRNA-769-5p, thereby increasing STAT3 expression

Figure 1. LINC00324 expression is high in retinoblastoma (RB) tumors and cell lines. (A) The expression of LINC00324 was determined in 47 RB tissue samples and 13 normal retinal tissue samples by RT-qPCR. *P < 0.05 vs. normal retinal tissue samples. (B) LINC00324 expression in three RB cell lines (Y79, SO-RB50, and WERI-RB-1) and in a normal retinal pigmented epithelial cell line, ARPE-19, was assessed via RT-qPCR. *P < 0.05 vs. ARPE-19 cells. (C) The relationship between LINC00324 expression and overall survival in the 47 patients with RB was evaluated via the Kaplan–Meier survival curve and log rank test. P = 0.021.