Research Paper Volume 12, Issue 9 pp 7729—7746

Long noncoding RNA LINC00324 promotes retinoblastoma progression by acting as a competing endogenous RNA for microRNA-769-5p, thereby increasing STAT3 expression

Figure 8. Reintroduction of STAT3 abolishes the actions of LINC00324 knockdown on RB cells. (AF) Y79 and WERI-RB-1 cells were cotransfected with si-LINC00324 and pcDNA3.1 or pc-STAT3. The proliferation, colony formation, apoptosis, cell cycle, migration and invasion was respectively determined by CCK-8 assay, colony formation assay, flow-cytometric analysis, and Transwell migration and invasion assays. *P < 0.05 vs. the si-NC group, #P < 0.05 vs. group si-LINC00324+ pcDNA3.1.