Research Paper Volume 12, Issue 13 pp 12684—12702

Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition

Figure 8. A mechanism graph of the lncRNA Sox2ot/miR-145/Egr1 axis involved in mice with Ang II-induced AAA. LncRNA Sox2ot competitively binds to miR-145 and negatively regulates its expression, thus upregulating the expression of Egr1 and then promoting the apoptosis, inflammatory reaction, and oxidative stress of VSMCs, which ultimately accelerates the occurrence of AAA induced by Ang II.