Online ISSN: 1945-4589

Volume 12, Issue 13

15 July, 2020
pp 12432—13844

About the Cover

The cover features Figure 1 "A healthspan pathway map for humans, including the list of pathways/clusters with their labels as assigned by AutoAnnotate and their size (number of genes)“ from Möller et al.


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Table of Contents

Priority Research Papers

COVID-19
Serum IgM against SARS-CoV-2 correlates with in-hospital mortality in severe/critical patients with COVID-19 in Wuhan, China

Xintian Liu, Xuan Zheng, Bo Liu, Mingxiang Wu, Zhenlu Zhang, Gangcheng Zhang, Xi Su,
https://doi.org/10.18632/aging.103417 pp 12432—12440
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Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

Franny Jongbloed, Ron W.F. de Bruin, Harry Van Steeg, Piet Beekhof, Paul Wackers, Dennis A. Hesselink, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Jan N.M. IJzermans,
https://doi.org/10.18632/aging.103619 pp 12441—12467
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Research Papers

COVID-19
Questionnaire assessment helps the self-management of patients with inflammatory bowel disease during the outbreak of Coronavirus Disease 2019

Meiping Yu, Zhenghao Ye, Yu Chen, Tingting Qin, Jiguang Kou, De’an Tian, Fang Xiao,
https://doi.org/10.18632/aging.103525 pp 12468—12478
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COVID-19
A qualitative study of the vocational and psychological perceptions and issues of transdisciplinary nurses during the COVID-19 outbreak

Jing Fan, Kaihui Hu, Xueqin Li, Ying Jiang, Xiang Zhou, Xin Gou, Xinyuan Li,
https://doi.org/10.18632/aging.103533 pp 12479—12492
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COVID-19
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis

Xiaoyu Fang, Shen Li, Hao Yu, Penghao Wang, Yao Zhang, Zheng Chen, Yang Li, Liqing Cheng, Wenbin Li, Hong Jia, Xiangyu Ma,
https://doi.org/10.18632/aging.103579 pp 12493—12503
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COVID-19
Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China

Shan Gao, Fang Jiang, Wei Jin, Yuan Shi, Leilei Yang, Yanqiong Xia, Linyan Jia, Bo Wang, Han Lin, Yin Cai, Zhengyuan Xia, Jian Peng,
https://doi.org/10.18632/aging.103631 pp 12504—12516
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Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing

Daniel J. Wilkinson, Giovanny Rodriguez-Blanco, Warwick B. Dunn, Bethan E. Phillips, John P. Williams, Paul L. Greenhaff, Kenneth Smith, Iain J. Gallagher, Philip J. Atherton,
https://doi.org/10.18632/aging.103513 pp 12517—12533
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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Dirk Repsilber, Hans Jörgen Grabe, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Brecht Wouters, Liliane Schoofs, Walter Luyten, Georg Fuellen,
https://doi.org/10.18632/aging.103514 pp 12534—12581
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Modulation of attention networks serving reorientation in healthy aging

Yasra Arif, Rachel K. Spooner, Alex I. Wiesman, Christine M. Embury, Amy L. Proskovec, Tony W. Wilson,
https://doi.org/10.18632/aging.103515 pp 12582—12597
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Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss

Federica Maria Spitale, Nunzio Vicario, Michelino Di Rosa, Daniele Tibullo, Michele Vecchio, Rosario Gulino, Rosalba Parenti,
https://doi.org/10.18632/aging.103561 pp 12598—12608
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Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice

Nicola Alessio, Mustafa B. Acar, Ibrahim H. Demirsoy, Tiziana Squillaro, Dario Siniscalco, Giovanni Di Bernardo, Gianfranco Peluso, Servet Özcan, Umberto Galderisi,
https://doi.org/10.18632/aging.103606 pp 12609—12621
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Fully bayesian longitudinal unsupervised learning for the assessment and visualization of AD heterogeneity and progression

Konstantinos Poulakis, Daniel Ferreira, Joana B. Pereira, Örjan Smedby, Prashanthi Vemuri, Eric Westman,
https://doi.org/10.18632/aging.103623 pp 12622—12647
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Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging

Ramy K. A. Sayed, Doaa M. Mokhtar, Marisol Fernández-Ortiz, José Fernández-Martínez, Paula Aranda-Martínez, Germaine Escames, Darío Acuña-Castroviejo,
https://doi.org/10.18632/aging.103654 pp 12648—12668
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Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion

Hesheng Ou, Hongli Teng, Yuwang Qin, Xuelan Luo, Peng Yang, Wenyu Zhang, Wei Chen, Dongning Lv, Huamin Tang,
https://doi.org/10.18632/aging.102792 pp 12669—12683
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Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition

Huyu Lin, Bin You, Xiandong Lin, Xiaohu Wang, Dongsheng Zhou, Zhiqun Chen, Yuanxiang Chen, Ren Wang,
https://doi.org/10.18632/aging.103077 pp 12684—12702
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Epigenomic and genomic analysis of transcriptome modulation in skin cutaneous melanoma

Wuzhen Chen, Pu Cheng, Jingxin Jiang, Yunqing Ren, Dang Wu, Dan Xue,
https://doi.org/10.18632/aging.103115 pp 12703—12725
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EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

Bingjie Cai, Min Li, Yunpeng Zheng, Yakun Yin, Fangcao Jin, Xuyang Li, Juan Dong, Xiaoyan Jiao, Xiaojun Liu, Kun Zhang, Dongqin Li, Junmin Wang, Guangwen Yin,
https://doi.org/10.18632/aging.103165 pp 12726—12739
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PAK4 suppresses TNF-induced release of endothelial microparticles in HUVECs cells

Shouqin Zhang, Yingjie Yin, Congye Li, Yi Zhao, Qixing Wang, Xiangyu Zhang,
https://doi.org/10.18632/aging.103173 pp 12740—12749
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Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Hao Yang, Cheng Chen, Hao Chen, Xiaojun Duan, Juan Li, Yi Zhou, Weinan Zeng, Liu Yang,
https://doi.org/10.18632/aging.103177 pp 12750—12770
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HOTAIR expands the population of prostatic cancer stem-like cells and causes Docetaxel resistance via activating STAT3 signaling

Ning Wang, Yaodong Jiang, Shidong Lv, Haoran Wen, Dehua Wu, Qiang Wei, Qiang Dang,
https://doi.org/10.18632/aging.103188 pp 12771—12782
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Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications

Huan Ren, Jian-Quan Luo, Yong-Chao Gao, Man-Yun Chen, Xiao-Ping Chen, Hong-Hao Zhou, Ying Jiang, Wei Zhang,
https://doi.org/10.18632/aging.103213 pp 12783—12798
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Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats

Xiangyu Chu, Tao Yu, Xiaojian Huang, Yang Xi, Bowei Ni, Rui Zhang, Hongbo You,
https://doi.org/10.18632/aging.103222 pp 12799—12811
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PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer

Hong-Kun Wu, Chang Liu, Xin-Xing Li, Wei Ji, Chen-De Xin, Zhi-Qian Hu, Lin Zhou,
https://doi.org/10.18632/aging.103246 pp 12812—12840
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miR-27-3p inhibition restore fibroblasts viability in diabetic wound by targeting NOVA1

Peng Zhang, Xiaomei Song, Qirong Dong, Long Zhou, Lei Wang,
https://doi.org/10.18632/aging.103266 pp 12841—12849
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Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway

Hui Fang, Kun Yang, Ping Tang, Na Zhao, Rui Ma, Xin Luo, Qi Liu,
https://doi.org/10.18632/aging.103304 pp 12850—12868
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miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression

Yu Wang, Yuejia Song, Yuxin Pang, Zihan Yu, Wei Hua, Yunhe Gu, Jiping Qi, He Wu,
https://doi.org/10.18632/aging.103343 pp 12869—12895
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A novel molecular-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma

Zhongjing Zhang, Wanqing Weng, Weiguo Huang, Boda Wu, Yi Zhou, Jie Zhang, Tuo Deng, Wen Ye, Jiecheng Zhang, Jianyang Ao, Qiyu Zhang, Keqing Shi,
https://doi.org/10.18632/aging.103350 pp 12896—12920
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Relationship between the expression of oestrogen receptor and progesterone receptor and 18F-FDG uptake in endometrial cancer

Chunhua Wu, Ruohua Chen, Lian Xu, Yumei Chen, Yining Wang, Gan Huang, Jianjun Liu,
https://doi.org/10.18632/aging.103352 pp 12921—12929
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Efficacy and safety of an antithrombotic regimen for atrial fibrillation patients with acute coronary syndrome or those undergoing percutaneous coronary intervention: a meta-analysis

Wenqin Guo, Xiehui Chen, Yunling Hao, Qiang Liu, Changnong Peng, Lingyue Zhao, Zongming Feng, Xiaoqing Wang, Huanjun Ruan, Lang Li,
https://doi.org/10.18632/aging.103359 pp 12930—12942
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Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1

Hui Dong, Zhuanzhuan Qiang, Dongdong Chai, Jiali Peng, Yangyang Xia, Rong Hu, Hong Jiang,
https://doi.org/10.18632/aging.103378 pp 12943—12959
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LOXL2 from human amniotic mesenchymal stem cells accelerates wound epithelialization by promoting differentiation and migration of keratinocytes

Dan He, Feng Zhao, Han Jiang, Yue Kang, Yang Song, Xuewen Lin, Ping Shi, Tao Zhang, Xining Pang,
https://doi.org/10.18632/aging.103384 pp 12960—12986
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Transcriptome analysis of common and diverged circulating miRNAs between arterial and venous during aging

Hao Wang, Yuan Zhou, Zhongnan Yin, Li Chen, Ling Jin, Qinghua Cui, Lixiang Xue,
https://doi.org/10.18632/aging.103385 pp 12987—13004
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MicroRNA-124 inhibits macrophage cell apoptosis via targeting p38/MAPK signaling pathway in atherosclerosis development

Xue Liang, Lijun Wang, Manman Wang, Zhaohong Liu, Xing Liu, Baoshuai Zhang, Enzhao Liu, Guangping Li,
https://doi.org/10.18632/aging.103387 pp 13005—13022
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The Gαh/phospholipase C-δ1 interaction promotes autophagosome degradation by activating the Akt/mTORC1 pathway in metastatic triple-negative breast cancer

Hui-Yu Lin, Chia-Hao Kuei, Hsun-Hua Lee, Che-Hsuan Lin, Jing-Quan Zheng, Hui-Wen Chiu, Chi-Long Chen, Yuan-Feng Lin,
https://doi.org/10.18632/aging.103390 pp 13023—13037
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circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis

Xu Pei, Shi-Wei Chen, Xiang Long, Shu-Qiang Zhu, Bai-Quan Qiu, Kun Lin, Feng Lu, Jian-Jun Xu, Peng-Fei Zhang, Yong-Bing Wu,
https://doi.org/10.18632/aging.103392 pp 13038—13058
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Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway

Yizhou Yao, Xuchao Wang, Diyuan Zhou, Hao Li, Huan Qian, Jiawen Zhang, Linhua Jiang, Bin Wang, Qi Lin, Xinguo Zhu,
https://doi.org/10.18632/aging.103393 pp 13059—13075
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CircFOXO3 rs12196996, a polymorphism at the gene flanking intron, is associated with circFOXO3 levels and the risk of coronary artery disease

Yu-Lan Zhou, Wei-Peng Wu, Jie Cheng, Li-Li Liang, Jin-Ming Cen, Can Chen, Xinguang Liu, Xing-Dong Xiong,
https://doi.org/10.18632/aging.103398 pp 13076—13089
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Changes of saliva microbiota in the onset and after the treatment of diabetes in patients with periodontitis

Ying Yang, Shili Liu, Yihua Wang, Zhibin Wang, Wenyu Ding, Xiaoyuan Sun, Kunlun He, Qiang Feng, Xiandang Zhang,
https://doi.org/10.18632/aging.103399 pp 13090—13114
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ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling

Muhong Guo, Ge Ma, Xiaolan Zhang, Weiwei Tang, Junfeng Shi, Qian Wang, Ye Cheng, Bin Zhang, Jin Xu,
https://doi.org/10.18632/aging.103400 pp 13115—13127
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Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice

Yan Diao, Junhui Nie, Peizhu Tan, Yuchen Zhao, Tingting Zhao, Jiajie Tu, Heng Ji, Yuwei Cao, Zhaojing Wu, Huan Liang, Hui Huang, Yanze Li, Xu Gao, Lingyun Zhou,
https://doi.org/10.18632/aging.103401 pp 13128—13146
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Articulation rehabilitation induces cortical plasticity in adults with non-syndromic cleft lip and palate

Zhen Li, Wenjing Zhang, Chunlin Li, Mengyue Wang, Songjian Wang, Renji Chen, Xu Zhang,
https://doi.org/10.18632/aging.103402 pp 13147—13159
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A validated survival nomogram for early-onset diffuse gastric cancer

Fei Liao, Xufeng Guo, Xiaohong Lu, Weiguo Dong,
https://doi.org/10.18632/aging.103406 pp 13160—13171
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An individualized transcriptional signature to predict the epithelial-mesenchymal transition based on relative expression ordering

Tingting Chen, Zhangxiang Zhao, Bo Chen, Yuquan Wang, Fan Yang, Chengyu Wang, Qi Dong, Yaoyao Liu, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Yan Xu, Yunyan Gu,
https://doi.org/10.18632/aging.103407 pp 13172—13186
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Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway

Zhi-Gang Mei, Ya-Guang Huang, Zhi-Tao Feng, Ya-Nan Luo, Song-Bai Yang, Li-Peng Du, Kang Jiang, Xiao-Lu Liu, Xian-Yun Fu, Yi-Hui Deng, Hua-Jun Zhou,
https://doi.org/10.18632/aging.103420 pp 13187—13205
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Altered circular RNA expression profiles in the non-ischemic thalamus in focal cortical infarction mice

Fangming Li, Chuqiao Li, Xiaoqiang Li, Yudi Li, Yulan Zhong, Li Ling,
https://doi.org/10.18632/aging.103424 pp 13206—13219
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Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5 promotes tumor growth and drug resistance in lung adenocarcinoma

Jia-Ru Wei, Jun Dong, Lei Li,
https://doi.org/10.18632/aging.103429 pp 13220—13233
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Increasing the expression of microRNA-126-5p in the temporal muscle can promote angiogenesis in the chronically ischemic brains of rats subjected to two-vessel occlusion plus encephalo-myo-synangiosis

Chuan Chen, Cong Ling, Jin Gong, Chao Li, Liying Zhang, Shuangqi Gao, Zhangyu Li, Tengchao Huang, Hui Wang, Ying Guo,
https://doi.org/10.18632/aging.103431 pp 13234—13254
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Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis

Juanyi Shi, Cheng Liu, Changhao Chen, Kaixuan Guo, Zhuang Tang, Yuming Luo, Luping Chen, Yinjie Su, Kewei Xu,
https://doi.org/10.18632/aging.103432 pp 13255—13280
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SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer

Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang,
https://doi.org/10.18632/aging.103433 pp 13281—13296
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Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation

Donge Tang, Xiaohui Liu, Kezhi Chen, Zhipeng Li, Yong Dai, Jiake Xu, Huan-Tian Zhang, Xuejuan Gao, Langxia Liu,
https://doi.org/10.18632/aging.103434 pp 13297—13317
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Subtype-specific risk models for accurately predicting the prognosis of breast cancer using differentially expressed autophagy-related genes

Baoai Han, He Zhang, Yuying Zhu, Xingxing Han, Zhiyong Wang, Zicong Gao, Yue Yuan, Ruinan Tian, Fei Zhang, Ruifang Niu,
https://doi.org/10.18632/aging.103437 pp 13318—13337
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circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway

Peng Zhou, Wei Xie, Hua-Lin Huang, Rong-Qi Huang, Chao Tian, Hong-Bo Zhu, Ying-Huan Dai, Zhi-Yuan Li,
https://doi.org/10.18632/aging.103438 pp 13338—13353
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IL-22 promotes tumor growth of breast cancer cells in mice

Ying Zhang, Cong Liu, Jun Gao, Siqi Shao, Yingying Cui, Songlou Yin, Bin Pan,
https://doi.org/10.18632/aging.103439 pp 13354—13364
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TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding

Xueyou Zhang, Panpan Ye, Haitao Huang, Baohong Wang, Fengqin Dong, Qi Ling,
https://doi.org/10.18632/aging.103442 pp 13365—13387
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PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+

Jinyu Zheng, Jian-liang Zhu, Yufeng Zhang, Hao Zhang, Yu Yang, De-Rong Tang, Jian Sun,
https://doi.org/10.18632/aging.103443 pp 13388—13399
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Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway

Zhaohui Liu, Yan Li, Lili Yu, Yulin Chang, Jingui Yu,
https://doi.org/10.18632/aging.103444 pp 13400—13421
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Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice

Lu Wan, Qing Zhang, Hongbin Luo, Zhendong Xu, Sheng Huang, Fumin Yang, Yi Liu, Yacoubou Abdoul Razak Mahaman, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wang,
https://doi.org/10.18632/aging.103445 pp 13422—13436
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Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment

Xing-Sheng Shu, Huazhang Zhu, Xiaoyan Huang, Yangfan Yang, Dandan Wang, Yiling Zhang, Weizhen Zhang, Ying Ying,
https://doi.org/10.18632/aging.103446 pp 13437—13462
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Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress

Zhongjie Liu, Shiyuan Xu, Zhonghua Ji, Huali Xu, Wei Zhao, Zhengyuan Xia, Rui Xu,
https://doi.org/10.18632/aging.103447 pp 13463—13476
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Hydrostatic pressure induces osteogenic differentiation of adipose-derived mesenchymal stem cells through increasing lncRNA-PAGBC

Jiangying Ru, Lieping Guo, Yinjun Ji, Yunfei Niu,
https://doi.org/10.18632/aging.103448 pp 13477—13487
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TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin

Weifeng Xu, Beibei Chen, Dianshan Ke, Xiaobing Chen,
https://doi.org/10.18632/aging.103451 pp 13488—13501
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Weighted correlation gene network analysis reveals a new stemness index-related survival model for prognostic prediction in hepatocellular carcinoma

Qiujing Zhang, Jia Wang, Menghan Liu, Qingqing Zhu, Qiang Li, Chao Xie, Congcong Han, Yali Wang, Min Gao, Jie Liu,
https://doi.org/10.18632/aging.103454 pp 13502—13517
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Association of the serum microRNA-29 family with cognitive impairment in Parkinson's disease

Linlin Han, Yilin Tang, Xiaochen Bai, Xiaoniu Liang, Yun Fan, Yan Shen, Fang Huang, Jian Wang,
https://doi.org/10.18632/aging.103458 pp 13518—13528
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Quantitative proteomics analysis of young and elderly skin with DIA mass spectrometry reveals new skin aging-related proteins

Jing Ma, Mengting Liu, Yaochi Wang, Cong Xin, Hui Zhang, Shirui Chen, Xiaodong Zheng, Xuejun Zhang, Fengli Xiao, Sen Yang,
https://doi.org/10.18632/aging.103461 pp 13529—13554
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Plasma acylcarnitine levels increase with healthy aging

Zachery R. Jarrell, M. Ryan Smith, Xin Hu, Michael Orr, Ken H. Liu, Arshed A. Quyyumi, Dean P. Jones, Young-Mi Go,
https://doi.org/10.18632/aging.103462 pp 13555—13570
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Altered complexity of resting-state BOLD activity in Alzheimer’s disease-related neurodegeneration: a multiscale entropy analysis

Ping Ren, Manxiu Ma, Guohua Xie, Zhiwei Wu, Donghui Wu, The Alzheimer's Disease Neuroimaging Initiative,
https://doi.org/10.18632/aging.103463 pp 13571—13582
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Super elderly patients with intertrochanteric fractures do not predict worse outcomes and higher mortality than elderly patients: a propensity score matched analysis

Junfei Guo, Zhiqian Wang, Mingming Fu, Jun Di, Junpu Zha, Junchuan Liu, Guolei Zhang, Qingxian Wang, Hua Chen, Peifu Tang, Zhiyong Hou, Yingze Zhang,
https://doi.org/10.18632/aging.103466 pp 13583—13593
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The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression

Ling Wang, Qian Nie, Meng Gao, Lan Yang, Jia-Wen Xiang, Yuan Xiao, Fang-Yuan Liu, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Quan Dong Nguyen, Yizhi Liu, Mugen Liu, David Wan-Cheng Li,
https://doi.org/10.18632/aging.103474 pp 13594—13617
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The YAP/SERCA2a signaling pathway protects cardiomyocytes against reperfusion-induced apoptosis

Jiankai Zhong, Haichun Ouyang, Sulin Zheng, Zhongzhou Guo, Yuying Chen, Yuanlin Zhong, Wenhao Zhong, Liuer Zuo, Jianhua Lu,
https://doi.org/10.18632/aging.103481 pp 13618—13632
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Melatonin protects against apoptosis of megakaryocytic cells via its receptors and the AKT/mitochondrial/caspase pathway

Mo Yang, Liang Li, Shichao Chen, Suyi Li, Bo Wang, Changhua Zhang, Youpeng Chen, Liuming Yang, Hongwu Xin, Chun Chen, Xiaojun Xu, Qing Zhang, Yulong He, Jieyu Ye,
https://doi.org/10.18632/aging.103483 pp 13633—13646
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MiR-146b-5p suppresses the malignancy of GSC/MSC fusion cells by targeting SMARCA5

Haiyang Wang, Liping Tan, Xuchen Dong, Liang Liu, Qianqian Jiang, Haoran Li, Jia Shi, Xuejun Yang, Xingliang Dai, Zhiyuan Qian, Jun Dong,
https://doi.org/10.18632/aging.103489 pp 13647—13667
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CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis

Linlin Yang, Bowen Wu, Zhaoxing Wu, Ying Xu, Ping Wang, Mengyuan Li, Rongzhen Xu, Yun Liang,
https://doi.org/10.18632/aging.103490 pp 13668—13683
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Genome-wide analyses of the prognosis-related mRNA alternative splicing landscape and novel splicing factors based on large-scale low grade glioma cohort

Wang-Rui Liu, Chuan-Yu Li, Wen-Hao Xu, Xiao-Juan Liu, Hai-Dan Tang, Hai-Neng Huang,
https://doi.org/10.18632/aging.103491 pp 13684—13700
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Exome sequencing identifies somatic mutations in novel driver genes in non-small cell lung cancer

Manman Zhang, Lele Zhang, Yan Li, Feng Sun, Ya Fang, Ruijia Zhang, Jin Wu, Guanbiao Zhou, Huaidong Song, Liqiong Xue, Bing Han, Cuixia Zheng,
https://doi.org/10.18632/aging.103500 pp 13701—13715
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Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo

Maximilian Fischer, Johanna Ruhnau, Juliane Schulze, Daniela Obst, Agnes Flöel, Antje Vogelgesang,
https://doi.org/10.18632/aging.103527 pp 13716—13739
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Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial

Amir Hadanny, Malka Daniel-Kotovsky, Gil Suzin, Rahav Boussi-Gross, Merav Catalogna, Kobi Dagan, Yafit Hachmo, Ramzia Abu Hamed, Efrat Sasson, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Sigal Tal, Yonatan Zemel, Yair Bechor, Shai Efrati,
https://doi.org/10.18632/aging.103571 pp 13740—13761
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Aging affects sex- and organ-specific trace element profiles in mice

Kristina Lossow, Johannes F. Kopp, Maria Schwarz, Hannah Finke, Nicola Winkelbeiner, Kostja Renko, Xheni Meçi, Christiane Ott, Wiebke Alker, Julian Hackler, Tilman Grune, Lutz Schomburg, Hajo Haase, Tanja Schwerdtle, Anna P. Kipp,
https://doi.org/10.18632/aging.103572 pp 13762—13790
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Reviews

COVID-19
Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage

Sisi Dong, Peipei Liu, Yuhan Luo, Ying Cui, Lilong Song, Yingzhu Chen,
https://doi.org/10.18632/aging.103511 pp 13791—13802
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Physical activity, a modulator of aging through effects on telomere biology

Maria Donatella Semeraro, Cassandra Smith, Melanie Kaiser, Itamar Levinger, Gustavo Duque, Hans-Juergen Gruber, Markus Herrmann,
https://doi.org/10.18632/aging.103504 pp 13803—13823
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Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling

Ricardo Gómez-Oliva, Noelia Geribaldi-Doldán, Samuel Domínguez-García, Livia Carrascal, Cristina Verástegui, Pedro Nunez-Abades, Carmen Castro,
https://doi.org/10.18632/aging.103510 pp 13824—13844
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