Research Paper Volume 12, Issue 9 pp 7801—7817

Age-related shifts in gut microbiota contribute to cognitive decline in aged rats

Figure 5. Gut microbiota of young recipient rats is reshaped by FMT. n = 5. (A) Shannon index. CK: before transplantation, FMT: fecal microbiota transplantation group (young rats, transplanted with microbiota from aged rats for 2 months), NFMT: non-fecal microbiota transplantation group (young rats, given PBS by gavage for 2 months). (B) Weighted UniFrac NMDS. F1-F5: FMT1-5, NF1-5: NFMT1-5. (C) UPGMA clustering analysis based on Weighted UniFrac distance. (D) Relative abundance of microbiota at phylum in each sample. (E) Phyla with significant differences between NFMT and FMT rats. (F) The ratio of F/B. (G) Heatmap at genus level; red represents an increase, and blue represents a decrease compared with NFMT rats. (H) Genera with significant differences between NFMT and FMT rats; * P < 0.05, ** P < 0.01 versus NFMT rats; #P < 0.05, ##P < 0.01 versus CK.