Research Paper Volume 12, Issue 9 pp 7801—7817

Age-related shifts in gut microbiota contribute to cognitive decline in aged rats

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Figure 6. Effect of FMT on cognition in young recipient rats. (A) Effect of FMT on cognitive behavior by DMTP task; n = 12. (B) Images of brain slices showing regions with lower ReHo in FMT group compared with NFMT group (n = 20, voxel level < 0.005, cluster level < 0.05 GRF corrected, and clusters > 50 voxels). Blue denotes decreased ReHo; the color bars indicated the T value between two groups. (C) Synaptic structures of mPFC and hippocampus in NFMT and FMT rats. n = 3. (D) Histograms of synaptic structure parameters. n = 3. (E) Expression of synaptophysin in mPFC and hippocampus. (FI) Golgi staining in NFMT and FMT rats (n = 3). Representative Golgi staining images of mPFC (F) and hippocampus (G) demonstrating impregnation of neurons. (H) Representative images of dendritic spines. (I) Histogram of dendritic spines densities; * P < 0.05 and ** P < 0.01 versus the NFMT group.