Research Paper Volume 12, Issue 9 pp 7830—7847

Intrarenal arteriosclerosis and telomere attrition associate with dysregulation of the cholesterol pathway

Figure 1. (A) List of the 9 significant canonical pathways associated with telomere length. The significance of the pathways is expressed as the Benjamini-Hochberg-adjusted p value (q value), which is corrected for multiple testing. The percentage on the left y axis represents the percentage of over- and lower expressed genes in the pathway. The numerical value at the top of each bar represents the total number of genes in the canonical pathway. Pathway analysis revealed enrichment of transcripts coding for proteins of the oxidative phosphorylation pathway (q=5.75x10-10), transcripts involved in the superpathway of cholesterol biosynthesis (q=2.96x10-8) and transcripts involved in the mitochondrial dysfunction pathway (q=1.26x0-6) as the first three most significant pathways. (B) List of the 3 significant canonical pathways associated with intrarenal arteriosclerosis. The significance of the pathways is expressed as the Benjamini-Hochberg-adjusted p value (q value), which is corrected for multiple testing. The percentage on the left y axis represents the over- and lower expressed genes in the pathway. The numerical value at the top of each bar represents the total number of genes in the canonical pathway. Pathway analysis revealed enrichment of transcripts coding for proteins of the superpathway of cholesterol biosynthesis (q=0.0003), transcripts involved in the superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (q=0.02) and transcripts involved in the mevalonate pathway I (q=0.03) as the three significant pathways.