Research Paper Volume 12, Issue 9 pp 7830—7847

Figure 2. The superpathway of cholesterol biosynthesis with the genes significant in the test cohort and validated in the validation cohort marked in yellow. LSS = lanosterol synthase, FDPS = farnesyl diphosphate synthase; DHCR7 =7-dehydrocholesterol reductase; HMGCR = 3-hydroxy-3-methylglutaryl-CoA reductase; FDFT1 = farnesyl-diphosphate farnesyltransferase 1; IDI1 = isopentenyl-diphosphate delta isomerase 1; ACAT2 = acetyl-CoA acetyltransferase 2; NSDHL = NAD(P) dependent steroid dehydrogenase-like; HMGCS1 = 3-hydroxy-3-methylglutaryl-CoA synthase 1; CYP51A1 =cytochrome P450, family 51, subfamily A, polypeptide 1; SQLE = squalene epoxidase; MSMO1 =methylsterol monooxygenase 1; MVD = mevalonate (diphospho) decarboxylase; HSD17B7 = hydroxysteroid (17-beta) dehydrogenase 7.