Research Paper Volume 12, Issue 9 pp 7830—7847

Intrarenal arteriosclerosis and telomere attrition associate with dysregulation of the cholesterol pathway

Figure 2. The superpathway of cholesterol biosynthesis with the genes significant in the test cohort and validated in the validation cohort marked in yellow. LSS = lanosterol synthase, FDPS = farnesyl diphosphate synthase; DHCR7 =7-dehydrocholesterol reductase; HMGCR = 3-hydroxy-3-methylglutaryl-CoA reductase; FDFT1 = farnesyl-diphosphate farnesyltransferase 1; IDI1 = isopentenyl-diphosphate delta isomerase 1; ACAT2 = acetyl-CoA acetyltransferase 2; NSDHL = NAD(P) dependent steroid dehydrogenase-like; HMGCS1 = 3-hydroxy-3-methylglutaryl-CoA synthase 1; CYP51A1 =cytochrome P450, family 51, subfamily A, polypeptide 1; SQLE = squalene epoxidase; MSMO1 =methylsterol monooxygenase 1; MVD = mevalonate (diphospho) decarboxylase; HSD17B7 = hydroxysteroid (17-beta) dehydrogenase 7.