Figure 12. Molecular mechanism of piperlongumine to achieve antitumor effect. (A) The interaction of the corresponding encoded proteins of 226 angiogenic genes regulated by piperlongumine. (B–C) The GO analysis (B) and the KEGG pathway analysis (C) of the 226 angiogenic genes. (D–E) Western blot analysis of SK-HEP1 (D) and SMMC-7721 (E) cell lines.