Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

Figure 1. Osthole attenuates CCI-induced mechanical and thermal hyperalgesia. (A, B) Paw withdrawal threshold and Paw withdrawal latency were both significantly decreased on POD 3, maintained on POD 7. The pain threshold values of osthole-treated and morphine-treated groups were increased day by day, approaching the value of the sham group on POD 10. ###p<0.01, compared with sham group; **p<0.05, ***p<0.01, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n = 6 mice/group. All data are means ± SD.