Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

Figure 4. Osthole induced synaptic inhibitory effects. (A) mEPSPs frequency was depressed by 100 μmol/L osthole, but mEPSPs amplitude did not show significant changes. (B) Osthole did not alter mEPSPs frequency and amplitude of normal mice. pCLAMP 10 software (Axon Instruments) were used to acquire and analyze the potential data. **p<0.05, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n = 6 mice/group. All data are means ± SD.