Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

Figure 6. The effect of osthole on Postsynaptic receptor pain-related signal molecules in neurons of CCI mice. (A) pGluA1 (ser845) and pGluN2B (S1303) were decreased after osthole treatment compared to CCI mice. (B) Osthole dose-dependently inhibited expression of p-ERK, p-CREB and c-Fos protein compared to CCI group. ###p<0.01, compared with sham group; **p<0.05, ***p<0.01, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n = 6 mice/group. All data are means ± SD.