Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

Figure 7. P2Y1 receptor-dependent JNK signaling pathway in spinal astrocyte was involved in pain relief after osthole treatment. (A) Single injection MRS2179, SP600125 and osthole all seriously changed the CCI-induced mechanical allodynia and heat hyperalgesia. (B) The effect of MRS2179, SP600125 and osthole on P2Y1R, p-JNK and c-Fos expression compared to CCI group. ###p<0.01, compared with sham group; ***p<0.01, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n=6 mice/group. All data are means ± S.D.