Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

Figure 8. Osthole exerts analgesic effect by directly acting on P2Y1 receptor of astrocyte. (A) P2Y1R expression in transfected cells markedly increase compared to normal astrocyte. (B) Astrocyte-conditioned medium induced the change trend of c-Fos consistent with that of P2Y1R. ###p<0.01, compared with sham group; ***p<0.01, compared with P2Y1R overexpression group, ANOVA followed by Bonferroni post-hoc test, n=6 mice/group. All data are means ± S.D.